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M9490477.TXT
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1994-09-19
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Document 0477
DOCN M9490477
TI On the antigenic diversity threshold model for AIDS.
DT 9411
AU Stilianakis NI; Schenzle D; Dietz K; Department of Medical Biometry,
University of Tubingen, Germany.
SO Math Biosci. 1994 Jun;121(2):235-47. Unique Identifier : AIDSLINE
MED/94331887
AB In this paper stochastic simulations of a model for AIDS pathogenesis
developed by Nowak and coworkers are presented. The results reveal a
strong dependency on initial conditions, and the model predicts a
nonmonotonic hazard rate for the transition to AIDS. Doubts are raised
concerning the significance of the antigenic diversity threshold, since
it only partially characterizes the model dynamics.
DE Acquired Immunodeficiency Syndrome/*ETIOLOGY Antigenic Variation Human
HIV/IMMUNOLOGY Mathematics *Models, Biological Stochastic Processes
Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Time Factors
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).